Top 5 Best, Worst, And Profitable Clinical Drugs

I know this is another out of my league topic but with my “clinical trial” readings, I came across these facts. I thought I’d share them with you.

Not all drugs that are subjected to clinical trials can be considered the best. These drugs were designed, developed, and produced by pharmaceutical companies with the goal of bringing cure to different kinds of illnesses. These drugs are tested and tried at clinical trials to ensure that they work as designed and that they are effective. They will not be made available until they pass all the clinical trials required and the results are successful.

Clinical trials date back to as early as the 17th century with the famous scurvy trial performed by James Lind in 1747. However, many studies reveal that even earlier than the 17th century, there are already clinical trials performed. There are also biblical instances that can be considered as clinical trials. For instance, in the New Testament, the king ordered Daniel and his friends to eat fruits and vegetables while the other men eat meat. In a way, many medical researchers consider this as a form of clinical trial. Truly, clinical trials has a rich history.

While there are many drugs that have successful results in the trials, there are also those that quite miss the mark. Some are considered failures. So what are the top 5 best drugs, top 5 worst drugs, and top 5 most profitable drugs in the field of clinical trials?

Top 5 Best Drugs 

These are the drugs that were developed by pharmaceutical companies. They have undergone a number of clinical trials and the results are successful. Because of this, they are approved by FDA as safe and beneficial to use. 

  1. Dapagliflozin

This drug was developed by Bristol-Myers Squibb alongside AstraZeneca. It is designed to help manage type II Diabetes. The drug controls the glycemic level of the patient. After successful clinical trials, the drug was approved by FDA in January 8, 2014. The company is currently performing clinical trials to see if the drug will be effective for type I diabetes.

  1. Glatiramer Acetate

This drug was developed by Teva Pharmaceuticals and is available by the brand name, Copaxone. It is an FDA approved drug that helps treat multiple sclerosis. It has undergone three major clinical trials that were all successful.

  1. Tasimelteon

This drug by Vanda Pharmaceuticals is a treatment for the sleep-wake disorder. Clinical studies and trials of the drug are all positive and they showed how effective the drug is in battling sleep-wake disorder.

  1. Ibrutinib

This is an anticancer drug created by Pharmacyclics. It is used to treat chronic acute leukemia. It targets B-cell malignancies. It is available under brand name Imbruvica. Clinical trials have been performed to test the efficacy of this drug and the results are very positive. The patients have improved conditions after the trial administration of the drug.

  1. Elosulfase Alfa

This is a drug that is marketed under the name of Vimizim and produced by BioMarin Pharmaceutical. It is used to treat a medical case called “Morquio Syndrome” which is basically the deficiency of N-acetylgalactosamine-6-sulfatase. The company performed clinical trials involving 176 participants and the results are satisfying.

Top 5 Worst Drugs

Some drugs were developed and they were subjected to a number of clinical trials. The results were not satisfying. They did not show effectiveness and because of this, they are considered failures in the field of clinical research. The pharmaceutical companies have discontinued the development of these drugs but not until they have already spent a great deal of budget. 

  1. Iniparib

This drug is designed for Stage IV lung cancer and platinum resistant ovarian cancer. It was not able to achieve its purpose after several clinical trials. The development of the drug and the clinical trials sponsored by Sanofi has an accumulated cost of $525 million. After failed results, the drug was considered a failure.

  1. Darapladib

This drug is designed to help cure heart disease in adults. It was produced and developed by GlaxoSmithKline. With an estimated overall cost of $246.3 million and no favourable medical results, this drug is surely a big failure. The company formally announced that this drug is a failure.

  1. Preladenant

One of the common illnesses of a lot of aged people is Parkinson’s disease. The drug “Preladenant” developed by Merck & Co., was designed to help treat Parkinson’s disease; however, after the failed phase III trials, the company decided not to pursue the clinical development program anymore. The cost of the development and trials reached $181 million.

  1. Fostamatinib

Designed to alleviate Rheumatoid arthritis, this drug from AstraZeneca and Rigel did not have successful clinical trials. The patients who received the drug during the trial period did not have any positive improvement in their cases. Thus, the drug was deemed ineffective. The cost incurred by the company is $136 million.

  1. Tabalumab

Another Rheumatoid Arthritis drug, the Tabalumab by pharmaceutical company, Eli Lilly, was considered a failure after not showing any efficacy after several clinical trials. The program was discontinued but it still accrued $60 million in cost.

Top 5 Most Profitable Drugs 

After successful clinical trials, drugs will be approved for use by FDA. They will be marketed and made available to the public either as an over the counter drug or prescription drug. Even though pharmaceutical companies spend millions on the development of the drug and the many clinical trials, they will still have good returns especially if the drugs they have developed are highly profitable. Do you ever wonder which drugs are most profitable? Here are the top 5:

  1. Remicade

This is a drug developed by Johnson & Johnson for rheumatoid arthritis. The total revenue of this drug is $74.3 billion. 

  1. Rituxan

This drug is developed by Biogen and Roche for rheumatoid arthritis and with a total revenue of $58.2 billion.

  1. Prevnar

This drug is developed by Pfizer to treat pneumococcal pneumonia. The total revenue is $49.6 billion.

  1. Avastin

This is developed by Roche as a treatment for different kinds of cancer. The total revenue is $48.5 billion.

  1. Herceptin

This is developed by Roche to help cure breast cancer and metastatic stomach/GEJ cancer. The total revenue is $48.5 billion.

So there you go, the list of the top 5 best drugs, top 5 worst drugs, and top 5 most profitable drugs in the medical industry today.



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